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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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Sinatra put his fame to use in ways other than the typical USO tours, none of which he made during the war.
Doin' it his way.[Click to View YouTube Video]
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zBrown
Ice climber
Brujo de la Playa
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May 10, 2014 - 10:35am PT
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With an assist from transgenic mice. There may be help afterall.
►KL-VS Genetic Variant of KLOTHO Is Associated with Enhanced Cognition in Three Independent Human Cohorts and in a Meta-Analysis
We therefore investigated whether klotho can impact physiological brain function and, more specifically, whether it can prevent or counteract cognitive decline in human aging. We demonstrate that the lifespan-extending variant of the KLOTHO gene, KL-VS, is associated with increased klotho levels in serum and enhanced cognition in aging people heterozygous for the allele in three cohorts and across multiple ages. We also analyzed transgenic mice with moderate systemic overexpression of klotho. Independent of age, these mice performed better in multiple tests of learning and memory than controls. Further investigation of potential underlying mechanisms revealed unexpected effects of klotho elevation on the functions of synapses and glutamate receptors.
http://www.cell.com/cell-reports/fulltext/S2211-1247(14)00287-3#
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 10, 2014 - 12:56pm PT
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Clotho was the daughter of Zeus and Themis, and sister to Lachesis and Atropos, according to Greek mythology. Clotho is also mentioned in the tenth book of the Republic of Plato as the daughter of Necessity, the Mother of Invention.
All you gotta know, really, but thanks.
What were we talking about?
[Click to View YouTube Video]Fate? And fingers?
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 10, 2014 - 02:47pm PT
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Phlogiston theory has to do with combustion and oxidation. It is outmoded.
It was good when it came around, just didn't explain things real well.
I like the idea of "inventing a necessity." It happens that oxidation is the reason we have graffiti, in my twisted logic. Phlogiston helped create thoughsands and thoughsands of jobs in the chemical industry, even thou it did not exist.
http://www.stencilarchive.org/node/1266
Apparently, according to this link, in 2010 U.S. spray-paint manufacturers produced 412 million cans.
That's a lot of boxcars.
It's the BNSF line.
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zBrown
Ice climber
Brujo de la Playa
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May 10, 2014 - 04:33pm PT
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**
more specifically, whether it can prevent or counteract cognitive decline in human aging.
Mark my words, in the future many will become "men of the klotho".
**Some may have already declined too far.
We better stop children
What's that sound?
Everybody look what's
Going down
Our field trip to the Library. First Nigerian rescue mission.
[Click to View YouTube Video]
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 10, 2014 - 04:49pm PT
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Leak Reveals Secret Underwater Thread Leading to Massive Dope Find in High Altitude Alpine County Lake is Rong.
Highlights at 11:00.
Licky Interview with the LostInShanghai Band to follow.[Click to View YouTube Video]
Turned out there was only one thing Jay could say:
"I don't want no more gosh-darn fickle,
I just want me a big dill pickle."
Just to help amuse
You non-climbing yahoos
[Click to View YouTube Video]No Republican laughter allowed.
Video provided by the Merry Braunsters Materials Handling Institute.
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 11, 2014 - 08:02am PT
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Flowers for all the mothers.
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 11, 2014 - 08:05am PT
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Unknown critter, blue eyes.
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zBrown
Ice climber
Brujo de la Playa
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May 11, 2014 - 10:28am PT
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Can you pass the Klotho test - approximately 20% can.
A gene variant associated with long lives in those people who possess it may also make them smarter by improving brain function, researchers say.
It has been known for at least decade people with high body levels of Klotho tend to live longer, and researchers wanted to know if the hormone could protect our brains from aging as well as the rest of the body.
On the waterfront (of the Lower Merced), although I am now officially boycotting the Ric&Scudmo show, I was wondering if anyone else finds it strange that after nine years our intredpid investigator is just now getting around to investigating what caused the plane to go down. Apparently this private eye is an 80 percenter.
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feralfae
Boulder climber
in the midst of a metaphysical mystery
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May 11, 2014 - 10:41am PT
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Thank you, Mouse, for all the lovely flowers today. I enjoyed every one!
Here, by way of a thank you, is some good music and a remarkably inspiring performance
http://www.youtube.com/watch?v=ob5UJS2WwQ8
enjoy, enjoy. :)
Best to you today. We are having a blizzard here in Montana.
feralfae
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lostinshanghai
Social climber
someplace
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May 11, 2014 - 07:01pm PT
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Yes Flowers for all the Mummies.
Brian sees me, I see him but not enough.
French Quarter section well close enough In Shanghaid
Any Business adventures this is where one goes well just one.
The hideout where all the underground to get the Japanese out of the country would make plans.
One that would drop bye.
Hotel and business. Had a temp office on second floor for a year.
In the bar and lounge area these pictures were on the wall. notice the pants on one chap.
A drive not too far away from downtown Shanghai where one could hide out.
Further North better place to hid.
Game of choice there, when an American wins three time in a row draws attention bringing in the biggies. "What American" Who? Now "CP Party Members" want to play you. P, no, P; No, I have to PP Oh! go PP then come back.
Just have to know
Smoke a lot of these.
Drink a few bottles
and take what the VA gives you before they have the time to get to see you which is usually within a year.
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 11, 2014 - 07:44pm PT
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Yep, Dr. Q's sight unseen, all right, but how sharp is his hatchet?
We had Dr. J in here last month, though.
And your jay, Jay, he's jake with me.
That's quite a tour we took just now...Britain...then a lovely Shanghai, if a bit menacing...and now we are heading to not-very-deep space.
In fact, it's nearly next door in terms of our solar system.http://sunnymeade.wordpress.com/2012/02/27/asteroid-97-klotho-passing-through-virgo/
http://www.natureworldnews.com/articles/6991/20140510/space-debris-could-create-real-life-gravity-lawmakers-say.htm
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lostinshanghai
Social climber
someplace
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May 11, 2014 - 09:06pm PT
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Took a while, moving, unmoving but finally
Now to erase. The ones I didn't should be showing up soon.
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 11, 2014 - 09:29pm PT
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Not peeking ducks and not on the pond, but the creek. Small floating, flying wood ducky objects. Plumage is nice, eh?Moving is for the birds. Too metamorphic. I'm more sedentary with a touch of igneous.
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 12, 2014 - 11:40pm PT
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Grown-ups love it, too![Click to View YouTube Video]
BBST, BTW.
[Click to View YouTube Video]Hump de bump doop bodu
Bump de hump doop bap
Hump de bump doop bodu
Bump de hump doop bodu
Hump de bump doop bap
Bump de hump doop bodu
Bump bump
-RHCP
Wide awake now?
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 13, 2014 - 10:31am PT
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For old Gene...up and at 'em, buddy!
Out for breakfast. These little birds are really tough to photograph in the date palms.
Bike racers among the date palms are a different kettle of metaphor.
For SCSeaGoat, wherever you're roaming now. Travel safely.
And the mice still are all over the place, neebee.These two are in the jasmine at the base of my reading lamp/quartz garden. One is next to a piece of rock from Bagby, the other is on a piece of obsidian from someplace. And there is a chunk of Tahquitz granite sitting there, as well.
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neebee
Social climber
calif/texas
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May 13, 2014 - 12:45pm PT
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hey there say, mouse... wow, happy to see and hear from you ... been a bit worried, but then, i REMEMBERED you had to use a library computer...
neat ducks, i love the way those ducks, SEEM to be painted, :)
say, great good morning sunrise, too!!
hope all your buddies are well there... and all the 12-to do friends, as well...
i STILL have fletcher's cookie cutter mouse to send, that my cat ate...
it will get there... just things were odd, of course, when my daddy was ill and died, :(
finally am getting caught up with things left on hold, here...
awwwwwww, i love seeing those mice all over the place... makes a house feel cozy, :) oh, wait, i think that is cats, that do that.... ;))
mice, keep a house BUSY, :)) you never know where they are running around at, :)
we got rain here... will be a non-sunny type summer, too, from the way the weather-computer-calendar looks...
say, i AM adding the gourds and color to the back of the painting but it is near done and i can even mail it after the weekend... but i will instead wait until the first week of june, as, i am at the 'scrape the bottom of the barrle' now, due to buying other canvas, etc... and,
a few things for my grandson, to send him...
so--this gives you time to 'hopefully' ask a few folks where she may be, for her to get the artwork... you don't have to tell what kind, just keep that part a surprise... i sure hope she will love it and that it will be a nice memory in her live, :)
welll,back to chores... finally cleaned the house and basement, wow!!
the ol' shed robin, has NOT nested this year, :(
i sure miss her and him... but, at least they, or other robins, ARE hopping in and out of the yard...
and,a scarlet tananger and her him, ARE nesting way out on the end of the ol' oak tree... great to see them!
a bit of sunshine, :))
happy good warm and productive day, to you mouse friend!
edit:
wow, love jasmine and rocks and the mice look great there!!!
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neebee
Social climber
calif/texas
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May 13, 2014 - 12:53pm PT
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hey there say, ... wow, just saw feralfae here...
yes, as to the the lovely mother's day flower, ...i just SAW THEM TOO, :))
very lovely share, thank you from us moms!
and, lostinshanghai, wow, loved seeing that nice mahjong... i love playing mahjong... not as highly skilled as the chinese, of course, or the serious players, as, i just had the step grandkids around to play with, and we just go for simple hands... :))
now, no one wants to play, as, they do not come around, they moved too far near out of town... and mahjong is not a game for those without patience, :))
OH--i meant that more in the way of setting it up...
the game can go quite fast, for those that get into it, :))
unless you go all 16 rounds, :O
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mouse from merced
Trad climber
The finger of fate, my friends, is fickle.
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May 13, 2014 - 03:33pm PT
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I like to play M-J on my computer. Dragon is my best set-up, and I'm making progress in winning more on the Fortress and the dreaded Cat!
There is a beauty of an antique M-J set over in the county courthouse museum, and BTW, I have my own computer back and don't need to rely on the library, shaddokiddo.
I'm glad the rest of the birds are showing up. It's dry as summer here already and predictions of 103 for this week have everyone a-scared and flapping like chickens, you'd think they lived in tropic paradise, not a desert with terrible air. Some people, mostly commuters, never stop to look at flowers or at bees or much of anything but their phones and bank accounts.
Purple flower, regular old giant bee, not a Lilabiene.
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