psychedelics, consciousness and things of beauty

Ayahuasca users actually had increased their Serotonin receptor sites and decreased or cured depression

"...At the vanguard of this research is Charles Grob, M.D., a professor of psychiatry and pediatrics at UCLA's School of Medicine. In 1993 Dr. Grob launched the Hoasca Project, the first in-depth study of the physical and psychological effects of ayahuasca on humans. His team went to Brazil, where the plant mixture can be taken legally, to study members of a native church, the União do Vegetal (UDV), who use ayahuasca as a sacrament, and compared them to a control group that had never ingested the substance. The studies found that all the ayahuasca-using UDV members had experienced remission without recurrence of their addictions, depression, or anxiety disorders. In addition, blood samples revealed a startling discovery: Ayahuasca seems to give users a greater sensitivity to serotonin—one of the mood-regulating chemicals produced by the body—by increasing the number of serotonin receptors on nerve cells.

Unlike most common antidepressants, which Grob says can create such high levels of serotonin that cells may actually compensate by losing many of their serotonin receptors, the Hoasca Project showed that ayahuasca strongly enhances the body's ability to absorb the serotonin that's naturally there.

"Ayahuasca is perhaps a far more sophisticated and effective way to treat depression than SSRIs [antidepressant drugs]," Grob concludes, adding that the use of SSRIs is "a rather crude way" of doing it. And ayahuasca, he insists, has great potential as a long-term solution. ..

What I learned was that studies had been done on members of the UDV, one of the religions that use the tea as a sacrament, which indicated ayahuasca was a powerful anti-depressant which treated the cause of the condition rather than the symptom. In short, most depression is caused by problems with the way the brain processes serotonin, which could be called the “mood” neurotransmitter. Prescription antidepressants work by various means to keep serotonin in the synapses longer. Ayahuasca contains DMT, which bonds to the 5-htp receptor sites, the same sites as serotonin. The DMT bonds at a higher rate, and the body adapts to this by increasing the number of 5-htp receptor sites, making better use of natural serotonin levels.

The UDV studies stated regular drinkers of the tea were less depressed, more social and more organized than the control groups, and that there were no physical or mental side effects to long term use in healthy individuals. Ayahuasca seemed to be an anti-depressant that treated the cause, had a better psychological outcome, and no side effects. The final factor in my decision was some of the people who I met at the conference. Many of them were long term drinkers of the tea from countries where it has been legalized. I found them to be some of the most grounded, sane, kind, and generally healthy people I had ever met.

Maybe there is no straight up yes or no afterall.